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. 2019 Dec 2;2019(12):CD003531. doi: 10.1002/14651858.CD003531.pub4

To 2008.

Methods Randomised, cross‐over study. Statisitical analysis based on paired t test.
Participants N = 43 participants (2 lost to follow‐up). BMI: 28.7 kg/m2; AHI: 54.3; ESS: 13.4
Inclusion criteria: 18 to 65 years; newly diagnosed OSA (AHI > 30)
Exclusion criteria: prior treatment for OSA
Interventions Auto‐CPAP versus fixed CPAP
Study duration: 2 x 8 weeks (washout: 1 week)
Outcomes

  1. Machine usage (average hours used)

  2. Symptoms (ESS)

  3. AHI

  4. Quality of life (SAQLI)

  5. Preference
Funding & conflicts of interest statements Quote: "The authors declared no conflict of interest between ResMed Company and the participating institutions, which received no external funding support for this study."
Notes TJL emailed for clarification of data from study author
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Patients were assigned by random table allocation into one of the two arms of the study."
Allocation concealment (selection bias) Low risk Quote: "Randomization was performed by an investigator external to the trial. The sequence of treatment group assignment was concealed from investigators conducting the screening and ongoing assessments.
Blinding of participants and personnel (performance bias) 
 Machine usage, symptoms, quality of life, withdrawal, adverse effects High risk Open‐label study
Blinding of participants and personnel (performance bias) 
 AHI, blood pressure, treatment pressure Low risk These outcomes unlikely to be affected by awareness of treatment group.
Blinding of outcome assessment (detection bias) 
 Machine usage, symptoms, quality of life, withdrawal, adverse effects High risk Open‐label study
Blinding of outcome assessment (detection bias) 
 AHI, blood pressure, treatment pressure Low risk These outcomes unlikely to be affected by awareness of treatment group.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Low rate of exclusions from the analysis (N = 2)
Selective reporting (reporting bias) Low risk All outcomes reported
Other bias Low risk No concerns identified