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. 2018 Jul 10;34(12):2057–2065. doi: 10.1093/ndt/gfy189

FIGURE 2.

FIGURE 2

Acute effects of rhEPO on FGF23 in wild-type mice with and without CKD. Groups included are wild-type mice, with and without adenine diet-induced CKD, intraperitoneally injected with a single dose of ∼67 U/g rhEPO or saline vehicle; at baseline (BL), 6 h postinjection and 24 h postinjection. Parameters shown are (a) serum urea nitrogen, (b) serum phosphate, (c) serum iron, (d) bone Fgf23 mRNA expression, (e) marrow Fgf23 mRNA expression, (f) plasma C-terminal (total) FGF23, (g) plasma intact FGF23 and (h) percentage intact FGF23. *Denotes a statistically significant pairwise comparison of an EPO-treated group versus baseline (P < 0.05, with subsequent Benjamini–Hochberg correction for multiple comparisons). #Denotes a statistically significant pairwise comparison of an EPO-treated group versus the saline-treated group at the same time point (P < 0.05, with subsequent Benjamini–Hochberg correction for multiple comparisons). Data are presented as mean and SD. n = 4–6 mice per group, with the exception of the baseline non-CKD group, which contained 8–20 mice, depending on the parameter measured.