Table 2.
Univariable and multivariable linear regression modeling of determinants of circulating total FGF23
| Parameter | Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| std. ß | P-value | std. ß | P-value | |
| EPO (IU/L) | 0.24 | <0.001 | 0.14 | <0.001 |
| Age (years) | 0.08 | 0.05 | ||
| Sex (male) (yes versus no) | 0.05 | 0.18 | −0.09 | 0.01 |
| Time since transplantation (years) | −0.04 | 0.36 | ||
| eGFR (mL/min/1.73 m2) | −0.50 | <0.001 | −0.38 | <0.001 |
| Calcium (mmol/L) | 0.01 | 0.78 | ||
| Phosphate (mmol/L) | 0.34 | <0.001 | 0.20 | <0.001 |
| PTH (pmol/L) | 0.17 | <0.001 | 0.12 | <0.001 |
| Ferritin (µg/L) | −0.34 | <0.001 | −0.33 | <0.001 |
| Hemoglobin (g/dL) | −0.37 | <0.001 | −0.09 | 0.005 |
| hs-CRP (mg/dL) | 0.19 | <0.001 | 0.14 | <0.001 |
Univariable linear regression analysis follow by multivariable stepwise backward linear regression analysis. cFGF23, EPO, ferritin, hs-CRP and PTH levels have been log-transformed due to skewed distribution.
hs-CRP, high-sensitivity C-reactive protein.