Table 3.

Examples of studies of pre-targeting RIT alone and in combination therapy with pre-targeted RIT studies.

Aim	Radionuclide	Cancer Type	Targeted Antigen	Subject	Combination	Reference
To determine maximum tolerated dose and antitumor efficacy of three-step pre-targeting method	90Y	Glioma	Tenascin	Human	No	[92]
Safe and effective with negligible toxicity pre-targeting RIT	90Y	LS-180, human carcinoma	Ep-CAM	BALB/c nude mice	No	[93]
Response to combination pre-targeted with less toxicity	90Y	LS174T, human colon adenocarcinoma	Tag-72 (CC49)	BALB/c nude mice	Gemcitabine	[94]