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. 2019 Nov 14;20(22):5716. doi: 10.3390/ijms20225716

Figure 7.

Figure 7

Summary of possibly involved mechanism in anti-tumor effect of celastrol on human gastric cancer cells. Celastrol targeting on inhibiting the expression of BGN significantly promotes the expression of RIP1 and RIP3 and the translation of MLKL from cytoplasm to plasma membrane, leading to the decrease of pro-inflammation cytokines’s production in human HGC-27 and AGScells.