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Main differences between uveal and cutaneous melanoma and their response to immunotherapy with check-point inhibitors.
| UVEAL | CUTANEOUS |
|---|---|
| 606 cases/year in Europe | 100,000 cases/year in Europe |
| Mainly liver metastasis | Metastasis in various organs |
| GNAQ or GNA11 gene mutations | BRAF or NRAS gene mutations |
| Monosomy 3 in 50% of tumors | Monosomy 3 rarely occurring |
| 0.8–5% positive responsiveness to immunotherapy | 20–60% positive responsiveness to immunotherapy |
