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. 2019 Nov 26;10:2736. doi: 10.3389/fimmu.2019.02736

Figure 2.

Figure 2

Viral loads and antibody responses. (A) Mice were fed on a high fiber or a no fiber diet for 3 weeks and were then infected with CHIKV (or left uninfected as controls). On day 6.5 and day 30 post infection feet were analyzed for CHIKV RNA by qRT PCR. Diet did not significantly affect CHIKV RNA levels (n = 4 mice and feet per group). (B) Mice were fed on a standard fiber and water was supplemented with butyrate or left unsupplemented (Water) and after 3 weeks mice were infected with CHIKV (or left uninfected as controls). Butyrate did not significant affect CHIKV RNA levels (n = 6 mice and feet per group). (C) Mice fed as for (A) with serum taken on day 30 post infection and assayed by ELISA for anti-CHIKV IgG2c or IgG1 antibody levels (n = 6 per group). (D) Mice with water supplementation as in (B), with serum taken on day 30 post infection and assayed by ELISA for anti-CHIKV IgG2c or IgG1 antibody levels (n = 6 per group).