Table III.
Univariate and multivariate analyses of disease-free survival in patients with colorectal cancer.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P-value | HR | 95% CI | P-value |
| MIR100HG | 3.658 | 1.956–6.893 | 0.001a | 4.105 | 1.809–6.842 | 0.001a |
| Age | 1.165 | 0.758–2.345 | 0.456 | – | – | – |
| Sex | 1.208 | 0.765–1.998 | 0.547 | – | – | – |
| Tumor size | 1.077 | 0.657–1.954 | 0.658 | – | – | – |
| Location | 0.895 | 0.384–1.848 | 0.506 | – | – | – |
| AJCC Stage | 4.924 | 1.264–5.831 | 0.002a | 5.264 | 1.249–6.048 | 0.001a |
| T classification | 1.216 | 1.851–2.536 | 0.035a | 1.768 | 1.959–2.833 | 0.027a |
| N classification | 1.659 | 1.181–2.611 | 0.032a | 1.937 | 1.349–3.117 | 0.022a |
| M classification | 3.786 | 1.854–4.594 | 0.003a | 3.853 | 2.432–4.897 | 0.001a |
| Differentiation | 1.821 | 1.125–2.543 | 0.021a | 2.018 | 1.275–3.958 | 0.023a |
| Vascular invasion | 1.354 | 0.872–1.685 | 0.183 | – | – | – |
a
P<0.05 indicates that the 95% CI of the HR did not include 1. AJCC, American Joint Committee on Cancer; HR, hazard ratio; MIR100HG, mir-100-let-7a-2-mir-125b-1 cluster host gene.