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. 2019 Nov 7;12(1):3–8. doi: 10.3892/mco.2019.1946

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Copyright: © Ponti et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — IHC of metastasis. Ileal metastasis tumor originating from subungual melanoma exhibits the same IHC profile of primitive neoplasia. It is characterized by an exclusive loss of expression of MSH6 protein when compared with MLH1, PMS2 and MSH2 status. In the analyzed metastases of the current cohort (e.g., gastric metastasis), the expression of MSH6 protein was preserved as with that of MLH1, PMS2 and MSH2 (scale bars, 100 µm). IHC, immunohistochemistry; MSH6, clone 44 Ventana; MLH1, clone M1 Ventana; PMS2, clone EPR3947 Ventana; MSH2, clone G219-1129; H&E, hematoxylin and eosin.