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. 2019 Nov 14;20(22):5718. doi: 10.3390/ijms20225718

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The hypervariable region (HVR) of K-Ras4B is unique and therefore it can influence several processes related to membrane binding and localization, protein–protein interactions, and posttranslational modifications (PTMs). (A) A cartoon of the Ras family proteins (N-Ras, H-Ras, K-Ras4A/B) shows the highly homologous G-Domain (1–165 aa) in green and the unique HVR of each isoform: N-Ras (Red); H-Ras (Blue); K-Ras4A (Purple); and K-Ras4B (Pink). The CaaX motif is shown in black. The unique polylysine region of K-Ras4B is colored light blue. (B) Key interactions of HVR with lipids (Rose), proteins (light Purple), and PTMs (Black) are highlighted. The predicted PTMs are shown in green and blue colors.