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The gross anatomical appearance post tamoxifen induction in (A) negative control (KRAS+/− and APC f/f), (B) positive control (CDX2 CRE ERT2 and APC f/f), and (C) model KPC: APC. (D) A portion of a colon of KPC: APC; (E) after the colon was cut longitudinally to expose the mucosa. Multiple small tumors are visible (arrow indicates one of them).
