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. 2019 Nov 6;20(22):5526. doi: 10.3390/ijms20225526

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

miR-221/AEG-1 regulates apoptosis and autophagy regulatory mRNAs in HCC cell line. The effect of miR-221/AEG-1 on PI3K, Akt, PTEN, OPN, Bcl-2, and LC3A mRNAs expressions analyzed in mock control, miR-mimic negative control, miR-Inhibitor negative control, miR-221 mimic, miR-221 Inhibitor, siRNA-negative control, and AEG-1 siRNA transfected HepG2, Huh7, and Hep3B cells by qRT-PCR using GAPDH as an internal control. Error bars are presented as mean ± s.d. and * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 compared with NC control group.