Figure 4.

Recruitment of c-MYC to the URI1 gene promoter in HCC-B tumor tissues. (A,B) Following chromatin immunoprecipitation (ChIP) with anti-c-MYC antibody, qPCR was performed with primers indicated in the figure. #; p < 0.05 was determined by paired Student’s t-test. NT, non-tumor tissues and T, tumor tissues from HCC-B patients. (C) Model describing HBx-induced URI1 expression through c-MYC in HCC-B. c-MYC induces URI1 expression through a non-canonical E-box in the URI1 promoter. HBx potentiates this action by enhancing the intracellular stability of c-MYC.