Figure 1.

IFN-γ deficiency leads to impaired wound healing in skin. Wounds were created on the backs of WT or IFN-γKO mice. (A) Wound photographs in WT or IFN-γKO mice. (B) Percentage of wound closure was evaluated on Days 5, 7, and 10. (C) Wound breaking strength was measured on day 14. (D) The number of myofibroblasts stained with anti-α-SMA antibody on Day 10. The myofibroblast density/mm2 was determined by counting the positive cells within six visual fields (n = 6). Arrows indicate the re-epithelialized leading edges. (E) Real-time PCR was performed to detect COL1A1, COL3A1, and TGF-β mRNA isolated from the wound. Each column represents the mean ± SD. * p < 0.05.