Table 5.

Transplant-Free Survival in the Pooled Cohort of Patients with Chronic Hypersensitivity Pneumonitis Categorized by MUC5B Minor Allele Status and Telomere Dysfunction

Variable*	HR	95% CI	P Value	n (%)
MUC5B−/TLD−	Ref	Ref	Ref	129 (40.2)
MUC5B+/TLD−	1.59	0.91–2.77	0.103	97 (30.2)
MUC5B−/TLD+	3.38	1.87–6.08	0.00005	53 (16.5)
MUC5B+/TLD+	3.52	1.87–6.62	0.00009	42 (13.1)

Definition of abbreviations: CI = confidence interval; HR = hazard ratio; MUC5B = mucin 5B gene; Ref = reference; TLD = telomere dysfunction.

^*Adjusted for age, sex, FVC % predicted, and self-reported race/ethnicity (non-Hispanic white vs. other). MUC5B− = homozygous wild-type (GG) for MUC5B rs35705950 SNP; MUC5B+ = at least one copy of the minor allele (GT or TT) for MUC5B rs35705950 SNP; TLD− = normal telomere length and absence of a qualifying telomere-related gene variant; TLD+ = short telomere length and/or presence of a qualifying telomere-related gene variant; comparison of MUC5B−/TLD+ to MUC5B+/TLD−, P = 0.006; MUC5B+/TLD+ to MUC5B+/TLD−, P = 0.0075; and MUC5B+/TLD+ to MUC5B−/TLD+, P = 0.89.