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The major classes of antimalarials and the corresponding target mutations responsible for resistance. (CYTb—Cytochrome b; K13—kelch 13 protein; DHPS—dihydropteroate synthetase; DHFR—dihydrofolate reductase; CRT—chloroquine resistance transporter; MDR1—multidrug resistance protein 1; MRP1—multidrug resistance-associated protein 1; NHE—Na+/H+ exchanger protein; ATP4—ATPase sodium efflux pump).
