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. 2019 Nov 14;20(22):5720. doi: 10.3390/ijms20225720

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The expression signature that is associated with survival outcomes in KIRC. (A) Kaplan–Meier curves show the overall survival of KIRC patients with a high and a low expression level of DLX4. Patients with a high expression level of DLX4 exhibited a significantly worse outcome compared with those with a low expression level of DLX4. A multivariable Cox regression analysis showed that DLX4 was an independent prognostic factor as compared with other confounding factors. (B) PYCR1 was found to be an independent prognostic marker for KIRC. A high expression level of this factor was associated with a worse outcome.