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. 2019 Nov 15;20(22):5747. doi: 10.3390/ijms20225747

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Representative immunoblots of protein expression levels: (A) kidney Bax, Bcl-2, HMGB1, and serum HMGB1; (B) kidney MnSOD and total and phosphorylated p38/Akt; and (C) kidney Nrf2 and HO-1. β actin was used as a loading control. Group categories abbreviations: S—sham operated rat group; S + M—sham operated + meldonium rat group; I/R—ischemia/reperfusion rat group; I/R + M—ischemia/reperfusion + meldonium rat group. Number of animals per experimental group: n = 8. Data are given as mean ± standard error. Minimal significant level: p < 0.05. Significantly different: ^a in respect to S; ^b in respect to S + M; ^c in respect to I/R group.