Table 2.
Activities of kidney copper-zinc superoxide dismutase (CuZnSOD, U/g wet mass), manganese superoxide dismutase (MnSOD, U/g wet mass), catalase (CAT, μmol H2O2/min/g wet mass), glutathione peroxidase (GSH-Px, μmol NADPH/min/g wet mass), glutathione reductase (GR, nmol NADPH/min/g wet mass), and glutathione S-transferase (GST, nmol GSH/min/g wet mass), as well as kidney concentrations of sulfhydryl groups (SH, nmol/g tissue) and lipid peroxides (TBARS, nmol/g tissue). Group categories abbreviations: S—sham operated rat group; S + M—sham operated + meldonium rat group; I/R—ischemia/reperfusion rat group; I/R + M—ischemia/reperfusion + meldonium rat group. Number of animals per experimental group: n = 8. The data are given as mean ± standard error. Minimal significant level: p < 0.05. Significantly different: a in respect to S; b in respect to S + M; c in respect to I/R group.
| Experiment Groups | S | S + M | I/R | I/R + M |
|---|---|---|---|---|
| CuZnSOD | 2183.12 ± 126.99 | 1531.98 ± 45.87 a | 2072.75 ± 93.81 b | 1231.84 ± 117.88 ac |
| MnSOD | 305.22 ± 22.94 | 644.35 ± 43.23 a | 250.98 ± 6.07 ab | 367.60 ± 32.99 bc |
| CAT | 15,323.99 ± 494.06 | 15,569.04 ± 440.31 | 12,832.91 ± 348.47 ab | 12,543.406 ± 512.92 ab |
| GSH-Px | 41.69 ± 2.22 | 43.27 ± 2.36 | 42.94 ± 3.034 | 24.80 ± 0.97 abc |
| GR | 16,495.17 ± 493.63 | 16,495.17 ± 696.70 | 16,495.17 ± 898.39 | 13,216.03 ± 277.42 abc |
| GST | 25,328.13 ± 727.06 | 25,496.88 ± 878.78 | 24,042.19 ± 837.08 | 25,667.19 ± 1002.05 |
| SH | 3955.56 ± 215.29 | 5240.88 ± 357.92 a | 3182.59 ± 105.86 ab | 4496.62 ± 559.32 c |
| TBARS | 1.24 ± 0.04 | 1.23 ± 0.03 | 1.44 ± 0.03 ab | 1.26 ± 0.04 c |