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. 2019 Nov 14;20(22):5700. doi: 10.3390/ijms20225700

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Water flux in tricellulin knockdown MDCK C7 cells stimulated by an osmotic gradient on the apical side of the cell layer. Water flux induced by a gradient of (a) 100 mM mannitol (n = 8–10), (b) 37 mM 4 kDa-dextran (n = 8–10) and (c) 100 mM 4 kDa-dextran (n = 6–9) was increased in both tricellulin knockdown clones, with the stronger increase in clone KD 24 with the higher reduction of tricellulin expression. Statistical analysis was performed using Student’s t-test between the KD clone and the corresponding control (KD 23 versus control 2, KD 24 versus control 9). (Control 2: ●; KD 23: ; Control 9: ◆; KD 24: . * p <0.05, ** p < 0.01, *** p < 0.001).

Inline graphic — Water flux in tricellulin knockdown MDCK C7 cells stimulated by an osmotic gradient on the apical side of the cell layer. Water flux induced by a gradient of (a) 100 mM mannitol (n = 8–10), (b) 37 mM 4 kDa-dextran (n = 8–10) and (c) 100 mM 4 kDa-dextran (n = 6–9) was increased in both tricellulin knockdown clones, with the stronger increase in clone KD 24 with the higher reduction of tricellulin expression. Statistical analysis was performed using Student’s t-test between the KD clone and the corresponding control (KD 23 versus control 2, KD 24 versus control 9). (Control 2: ●; KD 23: ; Control 9: ◆; KD 24: . * p <0.05, ** p < 0.01, *** p < 0.001).