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. 2019 Nov 15;20(22):5745. doi: 10.3390/ijms20225745

Figure 2.

Figure 2

Transcriptional level of catabolic genes matrix metalloproteinase (MMP) a) MMP1 b) MMP3 c) MMP13, pro-inflammatory gene d) cyclooxygenase 2 (COX-2) and anabolic marker genes e) collagen type II (COL-II) and f) aggrecan (ACAN) in Phase II (short term pellets) simultaneously treated with TCM compounds and IL-1β/TNF-α versus control vehicle (C vehicle) group in human OA chondrocytes. n = 3; n indicates the number of human OA donors; for each donor three experimental replicates were analyzed. Data are normalized to the levels of control groups. For statistical analysis using Graphpad Prism, one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test (multiple comparisons) was applied. * p < 0.01, ** p < 0.001, *** p < 0.0005, **** p < 0.0001, ns (non-significant).