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. 2019 Sep 17;6(4):342–358. doi: 10.1016/j.gendis.2019.09.008

Figure 2.

Figure 2

Physiologic wound healing. Following the initial wound, platelets and coagulation factors enter the wound bed from blood vessels and produce a fibrin clot through primary and secondary hemostasis. The fibrin clot is infiltrated by macrophages which function to phagocytose cellular debris and pathogens as well as releasing cytokines. These cytokines (including VEGF, FGF, and PDGF) summon fibroblasts and stimulate angiogenesis. Fibroblasts produce type III collagen for tissue repair. Angiogenesis allows sufficient transport of nutrients to the healing wound bed. Eventually the type III collagen is remodeled into type I collagen, which restores 60–80% of the original strength.