Table II.

Best gene-gene and gene-environment interaction models, as identified by generalized multifactor dimensionality reduction (GMDR)

Locus number	Best combination	Cross-validation consistency	Testing accuracy	p-value*
Gene-gene interaction
2	2, 3	6/10	0.522	0.324
3	2, 3, 1	7/10	0.514	0.255
4	2, 3, 1, 4	6/10	0.597	0.212
Gene-obesity interaction
2	1, 5	7/10	0.488	0.536
3	1, 2, 5	6/10	0.523	0.706
4	1, 2, 3, 5	5/10	0.536	0.862
5	1, 2, 3, 4, 5	6/10	0.518	0.377
Gene-abdominal obesity interaction
2	1, 6	10/10	0.641	0.012†
3	1, 2, 6	8/10	0.526	0.266
4	1, 2, 3, 6	9/10	0.514	0.545
5	1, 2, 3, 4, 6	5/10	0.634	0.372

^*Adjusted for age, smoking, and alcohol consumption status

^†Statistically significant

1, rs3003336; 2, rs2501431; 3, rs4237; 4, rs2229579; 5, obesity; 6, abdominal obesity