Table IV.
The association of genotype and allele within four single-nucleotide polymorphisms (SNPs) with osteoporosis (OP) risk
| Genotypes and alleles | Frequency, n (%) | OR (95% CI)* | p-value | HWE test | |
|---|---|---|---|---|---|
| OP case (n = 631) | Control (n = 636) | ||||
| rs2501431 | |||||
| TT | 314 (49.8) | 389 (61.2) | 1.00 | 0.390 | |
| TC | 250 (39.6) | 212 (33.3) | 1.36 (1.06 to 1.61) | 0.028† | |
| CC | 67 (10.6) | 35 (5.5) | 1.87 (1.26 to 2.50) | 0.001† | |
| TC+CC | 317 (50.2) | 247 (38.8) | 1.32 (1.11 to 1.69) | 0.013† | |
| T | 878 (69.6) | 990 (77.8) | |||
| C | 384 (30.4) | 282 (22.2) | |||
| rs4237 | |||||
| AA | 332 (52.6) | 365 (57.4) | 1.00 | 0.125 | |
| AG | 237 (37.6) | 224 (35.2) | 1.07 (0.94 to 1.39) | 0.425 | |
| GG | 62 (9.8) | 47 (7.4) | 1.12 (0.85 to 1.60) | 0.562 | |
| AG+GG | 299 (47.4) | 271 (42.6) | 1.09 (0.91 to 1.44) | 0.513 | |
| A | 901 (71.4) | 954 (75.0) | |||
| G | 361 (28.6) | 318 (25.0) | |||
| rs3003336 | |||||
| AA | 320 (50.7) | 397 (62.4) | 1.00 | 0.578 | |
| AG | 255 (40.4) | 208 (32.7) | 1.62 (1.36 to 1.88) | 0.0012† | |
| GG | 56 (8.9) | 31 (4.9) | 2.01 (1.61 to 2.80) | < 0.001† | |
| AG+GG | 311 (49.3) | 239 (37.6) | 1.71 (1.42 to 2.02) | < 0.001† | |
| A | 895 (70.9) | 1002 (78.8) | |||
| G | 367 (29.1) | 270 (21.2) | |||
| rs2229579 | |||||
| CC | 337 (53.4) | 371 (58.3) | 1.00 | 0.283 | |
| CT | 243 (38.5) | 223 (35.1) | 1.08 (0.91 to 1.36) | 0.287 | |
| TT | 51 (8.1) | 42 (6.6) | 1.04 (0.82 to 1.53) | 0.628 | |
| CT+TT | 294 (46.6) | 265 (41.7) | 1.07 (0.89 to 1.39) | 0.481 | |
| C | 917 (72.7) | 965 (75.9) | |||
| T | 345 (27.3) | 307 (24.1) |
*
Adjusted for age, smoking, and alcohol consumption status
†
Statistically significant
OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium