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. 2019 Oct 15;151(12):1347–1356. doi: 10.1085/jgp.201812264

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© 2019 Twomey et al.

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Figure 1. — Functional effects of auxiliary subunits. (A–C) Representative whole-cell currents recorded at −60 mV membrane potential from HEK cells expressing GluA2 (A), GluA2-STZ (B), or GluA2-GSG1L (C) in response to 1-s applications of the full agonist Glu alone (3 mM) or application of the partial agonist kainate (KA; 0.5 mM) or Glu in the continuous presence of the positive allosteric modulator cyclothiazide (CTZ; 30 µM). (D) Fraction of nondesensitized receptors (I_SS/I₀) and KA efficacy (I_KA/I₀) for GluA2 (black), GluA2-STZ (blue), and GluA2-GSG1L (red). (E) Two-pulse protocol monitoring recovery from desensitization for GluA2-GSG1L activated by Glu. (F) Mean recovery from desensitization measured using the protocol illustrated in E for GluA2 (black), GluA2-STZ (blue), and GluA2-GSG1L (red). The curves through the points are fits with the Hodgkin-Huxley equation with the time constant of recovery from desensitization 15.3 ± 1.1 ms for GluA2, 13.9 ± 0.9 ms for GluA2-STZ, and 164 ± 11 ms for GluA2-GSG1L. Error bars represent SEM. Modified from Twomey et al. (2016, 2017b).