Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 15;151(12):1347–1356. doi: 10.1085/jgp.201812264

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Twomey et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — Interfaces in an AMPAR–STZ complex. (A) Structure of an AMPAR (GluA2 homotetramer) bound to four STZ molecules in ribbon representation viewed parallel to the membrane (PDB accession no. 5WEO). The ATD has been excluded. Each GluA2 subunit is colored individually (A, dark blue; B, coral; C, light blue; D, dark orange), and STZ subunits are colored teal (X site) or pink (Y site). Boxed are regions illustrated in C–G. (B) Extracellular view on the TMD from right above the Q/R site. Membrane segments of one AMPAR subunit (B subunit M1-M4) and one STZ subunit (Y site, TM1-4) are labeled. (C) Interface between the LBD of the B subunit from the AMPAR and the β4-TM2 loop preceding the ECH of a X-site STZ molecule (A, inset I). (D) Electrostatic surface for the region shown in C, blue being positively charged, red negatively charged, and white neutral (A, inset I). (E) Potential interaction between an X-site TARP β1-β2 loop and A subunit LBD helix H (A, inset II). (F) Interface between a Y-site TARP TM3-β5 loop and S2-TM4 linker in the C subunit (A, inset III). (G) AMPAR–TARP interface in the TMD (A, inset IV).