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. 2019 Dec 2;7:64. doi: 10.1186/s40635-019-0274-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Arginine bioavailability. Arginine (ARG) is transported into the cell via cationic amino acid transporters and is converted to citrulline (Cit) and NO. Citrulline derived from a number of sources including diet can be converted to arginine by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) increasing the available intracellular arginine. Arginase (ARG) metabolises arginine to ornithine (Orn) and urea (Ur)