Fig. 7.

Effects of T-cell toxicity on L02 liver cells. The L02 liver cells and the T lymphocytes were cocultured to evaluate the toxicity of T lymphocytes to liver L02 cells. a T lymphocytes was activated by concanavalin A (Con A) that made the cytotoxic effect, and cell apoptosis of L02 liver cells was measured by Parp (89 kDa). b Statistical analysis showed that GW405833 (GW) inhibited T lymphocytes and protected L02 liver cells against T-cell toxicity. The cannabinoid receptor 2 (CB2R) antagonist (AM630) would counteract the protective effect. n = 3 for each group. Mean ± SEM. ***P < 0.001, ****P < 0.0001. ^nsP > 0.05