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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Neurobiol. 2019 Nov 8;59:213–220. doi: 10.1016/j.conb.2019.10.001

Figure 1: Neuron-type specific expression of cluster Pcdh genes (stochastic vs determinative).

Figure 1:

(A) Organization of the murine Pcdh gene clusters. White: Pcdhα alternate genes; Aqua: Pcdhβ genes; Grey: Pcdhγ alternate genes; Purple: c-type genes from the Pcdh α and γ clusters. Arrows indicate all the promoters of the Pcdh genes. (B) Example of a stochastic and combinatorial expression of Pcdh genes from all three clusters in olfactory sensory neurons (OSNs). (C) Example of a stochastic and combinatorial expression of Pcdh alternate genes from all three clusters in Purkinje neurons. In these neurons, the c-type are biallelically and constitutively expressed in every cell. (D) Example of a determinative expression of the sole cluster Pcdhαc2 in serotonergic neurons.

The expression of Pcdh genes shown in (B-C) is meant to summarize expression from both chromosomes, as the two chromosomes behave independently with regards to Pcdh promoter choice.