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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Neurobiol. 2019 Nov 8;59:213–220. doi: 10.1016/j.conb.2019.10.001

Figure 4: Model of stochastic Pcdhα alternate promoter choice.

Figure 4:

Coupling antisense lncRNA transcription to DNA demethylation mediates stochastic promoter choice of clustered Pcdhα alternate promoters by CTCF and Cohesin through DNA loop extrusion. This mechanism ensures that the choice of a Pcdhα alternate promoter occurs independently from the distance between the stochastically chosen promoter and the HS5–1 enhancer.