Table 2.
Baseline urinary biomarker excretion (n = 302)
| Urinary biomarker | All patients (n = 302) | Rapid progressors (n = 74) | Slow progressors (n = 78) | p value | |
|---|---|---|---|---|---|
| General, mg/24 h Albumin | 184.3 (144.4–240.3) | 196.3 (154.4–248.1) | 174.8 (132.7–211.7) | 0.02 | |
| Glomerular, mg/24 h IgG | 6.03 (3.59–10.82) | 7.18 (4.51–11.74) | 5.04 (3.38–9.52) | 0.02 | |
| Proximal tubular, µg/24 h β2MG | 191.2 (120.9–258.4) | 247.0 (168.8–307.8) | 183.1 (87.7–239.0) | <0.001 | |
| KIM-1 | 0.97 (0.67–1.35) | 1.06 (0.73–1.51) | 0.88 (0.61–1.19) | 0.04 | |
| Distal tubular, µg/24 h HFABP | 17.6 (12.2–25.4) | 21.9 (13.4–31.6) | 17.0 (12.4–22.8) | 0.005 | |
| Inflammatory | NGAL, µg/24 h | 39.4 (24.5–63.8) | 50.6 (29.9–76.7) | 34.8 (23.4–55.1) | 0.007 |
| MCP-1, ng/24 h | 517.9 (317.7–809.4) | 612.5 (421.0–944.9) | 374.8 (240.1–684.2) | 0.001 |
Variables are presented as median (IQR) and p values were calculated for rapid versus slow progressors with a Mann-Whitney U test. Rapid and slow progressors were defined as patients with an annual change in eGFR less than or equal to −3.5 or greater than −3.5 mL/min/1.73 m2, respectively.
IgG, immunoglobulin G; β2MG, β2 microglobulin; KIM-1, kidney injury molecule 1; HFABP, heart-type fatty acid-binding protein; NGAL, neutrophil gelatinase-associated lipocalin; MCP-1, monocyte chemotactic protein 1.