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. 2019 Feb 8;26(11):2223–2236. doi: 10.1038/s41418-019-0289-6

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© The Author(s) 2019

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Fig. 8 — Schematic representation of TS mediated BC de-differentiation. Excessive thymidylate is fluxed in the catabolic pathway for degradation mediated by DPYD. DPYD catalyzed DHT maintains the de-differentiation in BC