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. 2019 Dec 2;11:172. doi: 10.1186/s13148-019-0754-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The acceleration of epigenetic aging in VAT correlates with BMI in men. Panels a and d compare the distribution of DNA methylation (DNAm) age acceleration, defined as the residual from regressing DNAm age on chronological age, between men and women in blood (a) and visceral adipose tissue—VAT—(d). Boxplots represent the distribution of phenotype data with median (dark horizontal line) and interquartile range (box), and p stands for the p values obtained in Student’s t test for independent samples. The correlation between DNAm age acceleration and body mass index (BMI) in blood (b and c; red dashed line) and VAT (e and f, yellow dashed line) is shown separately in men and women. Residuals over zero (horizontal black line) stand for an acceleration of DNAm age, while r and p refer to Pearson correlation coefficients and p values, respectively. Blue and gray dots refer to men and women, respectively.