Table 3.

Results of the association parameter α obtained from the baseline Cox model, the TVCM and the joint model fitted to data generated considering the linear marker trajectory (scenario 2 of Table 1) with α∈(0,0.3,0.6) and σ_ε∈(0.1,0.3,0.5) with CV ∈(3.1%,9.4%,15.6%). Mean of the maximum likelihood estimates (Est), asymptotic standard error (ASE), bias, percentage bias (%Bias) and 95% coverage probabilities (CP) are shown

		α=0				α=0.3				α=0.6
σε	Model	Est	ASE	Bias	CP	Est	ASE	%Bias	CP	Est	ASE	%Bias	CP
	Cox.baseline	0.000	0.060	0.000	95	0.254	0.056	-15	86	0.545	0.059	-9.2	83
0.1	TVCM(1x/week)	-0.003	0.060	-0.003	96	0.293	0.058	-2.3	95	0.582	0.061	-3.0	93
	TVCM(4x/week)	-0.001	0.060	-0.001	95	0.298	0.059	-0.7	94	0.594	0.062	-1.0	94
	joint model	-0.003	0.059	-0.003	96	0.301	0.058	0.3	95	0.604	0.061	0.7	94
	Cox.baseline	0.000	0.058	0.000	96	0.240	0.054	-20	79	0.508	0.057	-15	62
0.3	TVCM(1x/week)	-0.003	0.058	-0.003	96	0.275	0.057	-8.3	92	0.541	0.059	-9.8	83
	TVCM(4x/week)	-0.001	0.058	-0.001	95	0.279	0.057	-7.0	92	0.550	0.059	-8.3	86
	joint model	-0.003	0.060	-0.003	95	0.301	0.059	0.3	95	0.604	0.064	0.7	94
	Cox.baseline	0.000	0.055	0.000	96	0.216	0.051	-28	61	0.449	0.053	-25	23
0.5	TVCM(1x/week)	-0.003	0.055	-0.003	96	0.244	0.053	-19	80	0.474	0.055	-21	35
	TVCM(4x/week)	-0.002	0.055	-0.002	95	0.247	0.054	-18	84	0.480	0.055	-20	40
	joint model	-0.004	0.062	-0.004	95	0.301	0.062	0.3	95	0.606	0.069	1.0	94