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. 2019 Dec 2;19:321. doi: 10.1186/s12935-019-1045-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Identification of FTO targeted genes. a Volcano plots showed 1635 up-regulated genes and 1240 down-regulated genes in FTO deficient Hela cells; b gene ontology analysis revealed up-regulated and down-regulated pathways in FTO knocking down cells; c gene set enrichment analysis (GSEA) of Hela cells with or without FTO deficiency