Table 3.
Selected list of HSF1 target genes identified in murine cell types, using the HSF1Base.
| Murine ’Shared’ HSF1 Target Genes | |||
|---|---|---|---|
| Ribosome biogenesis | |||
| Official Gene Symbol | Novelty (target not characterized in detail) | Regulatory information | |
| RPL7L1 | Yes | inhibited | |
| XPO1 | Yes | inhibited | |
| G2/M Checkpoints | |||
| Official Gene Symbol | Novelty (target not characterized in detail) | Regulatory information | |
| TOPBP1 | Yes | inhibited | |
| RAD1 | Yes | inhibited | |
| UBC | No | activated | |
| Oocyte | |||
| Sister chromatid segregation | |||
| Official Gene Symbol | Novelty (target not characterized in detail) | Regulatory information | |
| STAG3 | Yes | inhibited | |
| STAG2 | Yes | activated | |
| Spermatocyte | |||
| Cell–cell adhesion via plasma-membrane adhesion molecules | |||
| Official Gene Symbol | Novelty (target not characterized in detail) | Regulated directly by HSF1 | Regulatory information |
| CRB1 | Yes | N/D | N/D |
| TENM4 | Yes | N/D | N/D |
| CDH19 | Yes | N/D | N/D |
| CCDC141 | Yes | N/D | N/D |
| CDH12 | Yes | N/D | N/D |
| CDH18 | Yes | N/D | N/D |
| SDK1 | Yes | N/D | N/D |
| CNTN5 | Yes | N/D | N/D |
| CDH6 | Yes | N/D | N/D |
| CDH26 | Yes | N/D | N/D |
| NECTIN1 | Yes | N/D | N/D |
| CDH15 | Yes | N/D | N/D |
| CDH13 | Yes | N/D | N/D |
| CNTN6 | Yes | N/D | N/D |
| CDH2 | Yes | N/D | N/D |
| NECTIN3 | Yes | N/D | N/D |
| CDH10 | Yes | N/D | N/D |
| MYPN | Yes | N/D | N/D |
| CDH4 | Yes | N/D | N/D |
A table summarizing the HSF1 target genes identified, using the database HSF1base. Selected HSF1 target genes are ordered by functional categories, based on PANTHER analyses. A target gene is considered novel if it had not previously been characterized as a HSF1 target in a single-gene-analysis study. Regulatory information is ‘activated’ or ‘inhibited’ if there is evidence for HSF1 dependent up- or down-regulation of the expression of the given gene. ‘N/D’ means there is no regulatory information available.