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. 2019 Dec 2;11:176. doi: 10.1186/s13148-019-0780-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Manhattan plot of Model 1 (examining the overall changes of DNA-M from pre- to post-adolescence. The x-axis represents chromosome numbers [1 to 22]. The y-axis is −log10 transformed raw p values (−log₁₀p). CpGs with FDR-adjusted p value less than 0.05 were located above the dotted line. b Locations of the identified CpGs Model 1 (gender invariant DNA-M changes), n:%. Body includes the region of body and 1st Exon, and the promoter region includes TSS1500 and TSS200