Table 3.

Analysis of the effect of pubertal exposures on dynamic CpG sites replicated in ALSPAC

Pubertal exposures		CpG sites	Genes	Est. coeff.	p valueRaw	p valueAdj.
BMI10	BMI10 × gender$	cg08770870	RPH3AL	0.060	1.78 × 10−6	0.018
		cg19663246	PDE1C	0.038	3.86 × 10−6	0.020
	BMI10	cg08770870	RPH3AL	− 0.016	0.013	0.457
		cg19663246	PDE1C	0.002	0.70	0.945
Pubertal events	Age growth spurt	cg08134671	GNG7	− 0.059	7.15 × 10−7	0.007
	Female’s age of menarche	cg06271237	PLAGL1	− 0.028	7.91 × 10−6	0.081
Other pubertal exposures	Non-steroidal drugs	cg16384862	CWC15; KDM4D	− 0.161	1.23 × 10−7	0.001
		cg18552620	STK17A	− 0.206	1.66 × 10−7	0.001
		cg12170787	SBNO2	− 0.014	7.60 × 10−6	0.026
		cg00620824	HLA-C	− 0.029	3.93 × 10−5	0.080
		cg12054453	TMEM49	− 0.035	3.93 × 10−5	0.080
		cg11001739	MAD1L1	0.029	5.27 × 10−5	0.090
	Do you currently smoke (yes)	cg05575921	AHRR	− 0.742	1.0 × 10−13	3.40 × 10−10
		cg14753356	IER3	− 0.193	1.0 × 10−13	3.40 × 10−10
		cg26703534	AHRR	− 0.178	1.0 × 10−13	3.40 × 10−10
		cg24296397	BSN	0.094	7.25 × 10−7	0.002
		cg08709672	AVPR1B	− 0.098	1.09 × 10−6	0.002
		cg16391678	ITGAL	− 0.115	8.57 × 10−6	0.015
		cg20295214	AVPR1B	− 0.117	1.55 × 10−5	0.023
		cg21241889	TRAF1	− 0.070	2.36 × 10−5	0.030
		cg04885881	SRM	− 0.092	3.99 × 10−5	0.045
		cg08109568	FAN1	− 0.170	7.43 × 10−5	0.071
		cg08884752	SKI	− 0.078	7.63 × 10−5	0.071

[1] ^$Female is the reference group [2]. Est. coeff.: estimated regression coefficients for each risk factor [3]. p value_Raw: raw p values for each test [4]. p value_Adj: FDR-adjusted p values, and FDR-adjusted p values < 0.05 were in bold font. CpGs with FDR-adjusted p values < 0.1 were also included