Table 1.
ARDS Survivor Characteristics by Study1
| Baseline Variables | ICAP (N=99) | ALTOS (N=134) |
|---|---|---|
| Demographic and Clinical Characteristics | ||
| Age, years mean (sd) | 48.2 (14.0) | 48.9 (14.6) |
| Male, n (%) | 55 (55.6) | 68 (50.7) |
| BMI kg/m2 mean (sd) | 28.3 (6.8) | 31.0 (7.8) |
| Race n (%) | ||
| White | 58 (59.2) | 121 (90.3) |
| Black | 39 (39.8) | 9 (6.7) |
| Other | 1 (1.0) | 4 (3.0) |
| Primary lung injury n (%) | ||
| Pneumonia | 48 (50.0) | 85 (66.9) |
| Sepsis | 18 (18.8) | 20 (15.7) |
| Aspiration | 11 (11.5) | 11 (8.7) |
| Trauma | 5 (5.2) | 6 (4.7) |
| Transfusions | 5 (5.2) | 5 (3.9) |
| Other | 9 (9.4) | 0 (0) |
| Charlson Comorbidity Index, mean (sd) | 2.0 (2.2) | 1.1 (1.7) |
| Functional Comorbidity Index, mean (sd) | 1.5 (1.4) | 1.8 (1.3) |
| APACHE II score, mean (sd)2 | 23.8 (8.2) | 25.4 (7.8) |
| Ventilation duration, days mean (sd) | 12.7 (12.5) | 11.3 (10.1) |
| ICU length of stay, days mean (sd) | 17.8 (17.3) | 15.1 (11.9) |
| Hospital length of stay, days mean (sd) | 29.4 (22.8) | 22.2 (16.3) |
| 6 Month Physical Measures3 | ||
| Body Structure and Function Measures | ||
| FEV1, mean % predicted (sd) | 71.5 (18.9) | 78.8 (18.6) |
| Arm muscle area, mean % (sd) | 52.3 (12.3) | 44.7 (18.1) |
| MIP, mean % predicted (sd) | 83.8 (35.2) | 91.1 (31.0) |
| MMT, mean % maximum MRC score (sd) | 91.1 (8.7) | 92.5 (7.3) |
| Handgrip strength, mean % predicted (sd) | 77.7 (24.5) | 78.5 (25.2) |
| Activity Measures | ||
| 6MWT, mean % predicted (sd) | 58.5 (20.1) | 67.2 (19.7) |
| 4-m gait speed, mean (sd) in m/ sec (ALTOS only) | -- | 1.0 (0.3) |
| Participation Measures | ||
| Number of ADL dependencies, mean (sd) (range 0–6, ICAP only) | 0.2 (0.8) | -- |
| Number of IADL dependencies, mean (sd) (range 0–8, ICAP only) | 1.8 (2.1) | -- |
| FPI-Total score, mean (sd) (range: 0–2, ALTOS only) | -- | 2.0 (0.6) |
| 6 Month Patient-Centered Outcomes3 | ||
| Alive and living at home, n (%) | 92 (96.8) | 125 (94.0) |
| SF-36 PCS score, mean (sd) | 39.7 (11.3) | 38.5 (11.6) |
| EQ-5D Utility score, mean (sd) | 0.8 (0.2) | 0.7 (0.2) |
| 12 Month Patient-Centered Outcomes3 | ||
| Alive to 12 months, n (%) | 95 (96.0) | 129 (96.3) |
| No hospitalization, n (%) between 6 and 12 months | 59 (72.8) | 98 (78.4) |
| Alive and living at home, n (%) | 88 (93.6) | 120 (90.2) |
| SF-36 PCS score, mean (sd) | 41.4 (10.5) | 41.4 (12.8) |
| EQ-5D Utility score, mean (sd) | 0.8 (0.2) | 0.7 (0.2) |
Abbreviations: sd: standard deviation; BMI: Body mass index; kg/m2: kilogram per meter squared; APACHE: Acute Physiology and Chronic Health Evaluation; ICU: intensive care unit; FEV1: forced expiratory volume in 1 second; MIP: maximal inspiratory pressure; MMT: manual muscle testing; MRC: Medical Research Council; 6MWT: six minute walk test; 4-m: 4-meter; m/sec: meter per second; ADL: activities of daily living; IADL: instrumental activities of daily living; FPI: Functional Performance Inventory; SF-36 PCS: Medical Outcomes Short-Form 36 Physical Component Score; EQ-5D: Euro-QOL.
Only ARDS patients who survive to 6 month follow-up are included in this study.
Estimated APACHE II score based on conversion from APACHE III to APACHE II (Reference: Schneider et al., J Crit Care 2013;28:885–888).
Based on non-missing values; Missing values—6-month physical measures (none for any variable in both studies); 6-month outcome (alive at home, N=4, 4% for ICAP, N=1, 0.7% for ALTOS; SF-36 PCS, N=0 for ICAP and ALTOS; EQ-5D, N=0 for ICAP, N=1, 0.7% for ALTOS); 12-month outcomes (alive to 12 months, N=0 for ICAP and ALTOS; No hospitalization, N=18, 18.2% for ICAP, N=9, 6.7% for ALTOS; alive at home, N=5, 5.0% for ICAP, N=1, 0.7% for ALTOS; SF-36 PCS, N=9, 9.1% for ICAP, N=10, 7.5% for ALTOS; EQ-5D, N=8, 8.1% for ICAP, N=9, 6.7% for ALTOS).