Table 4.
Multivariable Associations of 6 Month Physical Measures with 6 Month Patient-Centered Outcomes
| Alive at homea At 6 month Odds Ratio (95% CI) | SF-36 PCS At 6 month Beta (95% CI) | EQ-5D Utility At 6 month Beta (95% CI) | ||||
|---|---|---|---|---|---|---|
| 6 Month Physical Measures | ICAP | ALTOS | ICAP | ALTOS | ICAP | ALTOS |
| N=95 | N=133 | N=99 | N=134 | N=99 | N=133 | |
| Body Structure & Function | ||||||
| FEV1, each 10% predicted | 1.46 (0.53,4.02) | 0.88 (0.55,1.39) | 0.00 (−1.12,1.12) | 0.76 (−0.14,1.65) | −1.09 (−2.98,0.79) | 0.60 (−1.07,2.27) |
| % muscle area, each 10% | 1.91 (0.58,6.24) | 0.94 (0.61,1.45) | 2.21 (0.57,3.85)** | −0.39 (−1.32,0.54) | 1.80 (−0.97,4.56) | −0.31 (−2.04,1.42) |
| MIP, each 10% predicted | 0.90 (0.54,1.50) | 0.99 (0.76,1.30) | 0.19 (−0.45,0.83) | 0.31 (−0.25,0.87) | 0.37 (−0.70,1.44) | 0.45 (−0.59,1.49) |
| MMT, each 10% max MRC score | 1.12 (0.18,7.06) | 0.89 (0.27,2.91) | 0.56 (−1.94,3.06) | 2.19 (−0.36,4.73) | −0.57 (−4.78,3.65) | 1.57 (−3.23,6.36) |
| Grip strength, each 10% predicted | 0.76 (0.39,1.49) | 0.97 (0.67,1.40) | −0.32 (−1.24,0.59) | −0.34 (−1.02,0.34) | −0.94 (−2.48,0.60) | −0.67 (−1.94,0.60) |
| Activity | ||||||
| 6 min walk, each 10% predicted | 1.86 (0.80,4.32) | 1.32 (0.83,2.09) | 1.52 (0.37,2.66)* | 0.99 (0.03,1.94)* | 2.77 (0.84,4.70)** | 0.59 (−1.20,2.37) |
| 4 meter walk speed (per 0.11 m/s) | -- | 0.94 (0.69,1.29) | -- | 0.55 (−0.13,1.23) | -- | 1.17 (−0.09,2.44) |
| Participation | ||||||
| No. ADL dependencies (ICAP only) | 0.49 (0.12,1.99) | -- | 0.63 (−1.86,3.12) | -- | −0.14 (−4.34,4.05) | -- |
| No. IADL dependencies (ICAP only) | 0.91 (0.46,1.80) | -- | −1.88 (−2.94,−0.82)** | -- | −2.50 (−4.28,−0.72)** | -- |
| FPI-Total, per 0.20 unit‡ (ALTOS only) | 1.17 (0.87,1.56) | 1.52 (0.89,2.15)** | 3.67 (2.50,4.84)** | |||
| Model Fit; Variance Explained | AUC=0.88 | AUC=0.75 | R2=0.29 | R2=0.43 | R2=0.17 | R2=0.41 |
Abbreviations: FEV1: forced expiratory volume in 1 second; MIP: maximal inspiratory pressure; MMT: manual muscle testing; MRC: Medical Research Council; 6MWT: six minute walk test; 4-m: 4-meter; m/sec: meter per second; ADL: activities of daily living; IADL: instrumental activities of daily living; FPI: Functional Performance Inventory; SF-36 PCS: Medical Outcomes Short-Form 36 Physical Component Score; EQ-5D: Euro-QOL.
p≤0.05;
p≤ 0.01;
Alive at home outcome for 6m (Yes=1, No=0; ICAP: 1, n=92, 97%, 0, n=3, 3%; ALTOS: 1, n=125, 94%; 0, n=8, 6%);
0.11 m/sec is an estimated MCID for the 4-m gait speed test based on prior study among COPD patients (Reference: Kon et al. Eur Respir J. 2014;43(5):1298–1305);
= Measure not available in dataset;
0.20 is an estimated MCID for the Functional Performance Inventory. There was no evidence of multi-collinearity (Variance inflation factor ≤ 1.59 for independent variables estimated within each models).