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. 2019 Sep 19;216(12):2701–2713. doi: 10.1084/jem.20190738

Figure 2.

Figure 2.

Early corticosteroid treatment reduces antitumor activity by anti–PD-L1 mAb. (A–C) Experimental schema (A) and tumor growth curves (B: mean; C: individual mice) of early corticosteroid treatment. BALB/c mice were inoculated with CT26-NY-ESO-1 and injected with anti–PD-L1 mAb on days 3, 6, and 9 after tumor inoculation. Corticosteroid administration was started on the same day of anti–PD-L1 mAb (n = 5–10). (D–F) Experimental schema (D) and tumor growth curves (E: mean; F: individual mice) of late corticosteroid treatment. BALB/c mice were inoculated with CT26-NY-ESO-1 and injected with anti–PD-L1 mAb on days 3, 6, and 9 after tumor inoculation. Corticosteroid administration was started on day 17 (n = 5 or 6). Data in B and E are mean + SE. Statistical analysis by Student’s t test; *, P < 0.05. These experiments were performed independently three times with similar results.