Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 10;216(12):2724–2735. doi: 10.1084/jem.20182351

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Takezaki et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — Enhanced ER stress in AEII cells from Sfpta1-KI mice. (a) Western blot showing levels of phosphorylated IRE1α and actin in AEII cells of 20-wk-old WT and Sftpa1-KI (KI) mice 7 d after infection with IAV or uninfected WT and KI mice at 20 wk of age. Data represent the means ± SD. *, P < 0.05; **, P < 0.01. (b) Flow cytometric analysis of phosphorylated JNK in WT mice, day 7 IAV-infected Sftpa1-KI or WT mice, or Sftpa1-KI mice infected with IAV and treated with IRE1α inhibitor. Data represent the means ± SD. **, P < 0.01. (c) Survival of WT (closed squares), Sftpa1-KI (open circles), or Sftpa1-KI (closed circles) mice at the age of 20 wk treated with a JNK inhibitor after IAV infection (number of mice in each independent experiment is 10). *, P < 0.05 by log-rank test. Quantification of hydroxyproline contents in WT or Sftpa1-KI mice (number of mice in each independent experiment is 10) 12 d after IAV infection. Data represent the means ± SD. *, P < 0.05. (d) RIPK3 expression in AEII cells in 20-wk-old WT and Sftpa1-KI mice, 20-wk-old WT and Sftpa1-KI mice 7 d after infection with IAV, and 20-wk-old KI mice 7 d after infection with IAV and treated with a JNK inhibitor. Data represent the means ± SD. **, P < 0.01. Data shown are representative of five (c and d) independent experiments or cumulative of five (a and b) independent experiments.