Figure 3. Fear is associated with reduced cortical thickness in multiple structural covariance networks.

Mass-univariate analyses using GAMs that controlled for linear and nonlinear age, sex, and image quality revealed that fear symptoms were associated with reduced cortical thickness in multiple networks. This association was maximal in networks such as the temporal-parietal junction and posterior cingulate cortex (Figure 3A; network 16). Significant associations were also present in networks that included the anterior cingulate, anterior insula, and subgenual cingulate cortex (Figure 3C; network 13). Composite network boundaries were obtained by assigning each voxel to one of the 18 networks with the highest loading for that voxel. Multiple comparisons were accounted for using the False Discovery Rate (Q<0.05). Dotted lines on scatterplots represent the 95% confidence interval.