Skip to main content
. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Struct Biol. 2019 Jun 21;59:98–106. doi: 10.1016/j.sbi.2019.05.009

Figure 4. Activation of Set1 in COMPASS.

Figure 4.

(a) Superposition of the Set1 catalytic domain (PDB: 6CHG, magenta) with MLL1 in different states (PDB: 5F6L, 5F5E, 2W5Y) showing different conformations of the SET-I helix. (b) Superposition of the Set1 catalytic domain (PDB: 6CHG, magenta) with MLL3 in different states (PDB: 5F6K chain C, E and 5F59) showing different conformations of the SET-I helix. (c) details of the SMART loop interactions with the SET-I helix of Set1 in COMPASS. The SMART loop in the crystal structure is colored orange and the SMART loop in the cryo-EM structure is colored tan.