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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Cancer Res. 2019 May 29;79(14):3702–3713. doi: 10.1158/0008-5472.CAN-18-3800

Figure 2. Leukemia-cell calcineurin is essential for immune evasion during progression of lymphoid and myeloid leukemia.

Figure 2.

A. Luciferase signal over time (left) and overall survival (right) in WT or Rag1−/− recipients of shNS or shCnB B-ALL (n=6/group from 2 independent experiments). B. Luciferase signal over time (left) and overall survival (right) in WT or Tcra−/− recipients of shNS or shCnB B-ALL (n=9/group from 2 independent experiments). C. c1498 acute myeloid leukemia cells were transduced with shNS or shCnB and injected into un-irradiated WT or Tcra−/− recipients. Overall survival is demonstrated. (n=15 WT and n=13 Tcra−/− recipients for each group from 3 independent experiments.) D. Western blot for CnB from B-ALL cells cultured in vitro or recovered from recipient mice at the time of euthanasia due to leukemia progression.