Table 2.
Sleep symptoms in patients with frontotemporal dementia and genetic mutations.
| Age (decade) | Sx (yrs) | Syndrome | Gene | Sleep symptoms |
|||
|---|---|---|---|---|---|---|---|
| Time overnight in bed (mean hours) |
Difficulty sleeping | Daytime somnolence | Disruptive sleep events | ||||
| 7th | 10 | bvFTD | GRN | 7.5 | + | – | – |
| 7th | 1 | bvFTD | GRN | 6.5 | + | + | – |
| 7th | 1 | PNFA | GRN | 9.5 | + | + | – |
| 7th | 10 | bvFTD | MAPT | 9.5 | + | + | – |
| 6th | 6 | SD | MAPT | 8.0 | + | – | – |
| 7th | 9 | bvFTD | C9orf72 | 4.0 | + | + | + |
| 8th | 11 | bvFTD | C9orf72 | 8.5 | + | + | + |
| 7th | 5 | bvFTD | C9orf72 | 10.5 | + | – | + |
| 7th | 6 | bvFTD | C9orf72 | 6.5 | + | + | + |
+, sleep symptom present; -, sleep symptom absent; C9orf72, mutation in chromosome 9 open reading frame 72; bvFTD, behavioural variant frontotemporal dementia; GRN, mutation in progranulin gene; MAPT, mutation in microtubule-associated protein tau gene; PNFA, progressive nonfluent aphasia; SD, semantic dementia; Sx, symptoms (duration in years).