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. 2019 Dec 2;9:18118. doi: 10.1038/s41598-019-54741-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AGS increases TERT and neuronal gene expression levels in Aβ treated cultures. Cultures were treated for 36 hr. with AGS-499 (200 nM) alone, Aβ (5 µM) alone, and Aβ (5 µM) in combination with AGS-499 (200 nM) or its vehicle DMSO. AGS or DMSO treatments were renewed after 24 hr. Genes Expression levels were quantified using RT-PCR and normalized to the untreated control (Control). (a) Relative TERT gene expression in cultures (Mean ± SEM, n = 5 independent experiments), ANOVA test *p < 0.05, ***p < 0.001. (b) Relative NeuN gene expression in cultures (Mean ± SEM, n = 4 independent experiments), ANOVA test **p < 0.01, ***p < 0.001. (c) Relative GAP43 gene expression in cultures (Mean ± SEM, n = 4 independent experiments), ANOVA test *p < 0.05, **p < 0.01. (d) Relative SYP gene expression in cultures (Mean ± SEM, n = 4 independent experiments), ANOVA test **p < 0.01, ***p < 0.001.