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. 2019 Dec 2;9:18118. doi: 10.1038/s41598-019-54741-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AGS increases the expression of TERT and neuronal genes in vivo. Mice were injected subcutaneously with AGS-499 in a concentration of 6 mg /kg of body mass. After 12 hr., mice were sacrificed. Expression levels were quantified using RT-PCR and normalized to the untreated control (Control). (a) Relative TERT gene expression in-vivo, in hippocampi (Mean ± SEM, n = 7 mice per group), ANOVA test ****p < 0.0001. (b) Relative NeuN gene expression in-vivo, in hippocampi (Mean ± SEM, n = 7 mice per group), ANOVA test **p < 0.01, ***p < 0.001. (c) Relative GAP43 gene expression in-vivo, in hippocampi (Mean ± SEM, n = 7 mice per group), ANOVA test ****p < 0.0001. (d) Relative SYP gene expression in-vivo, in hippocampi (Mean ± SEM, n = 7 mice per group), ANOVA test ****p < 0.0001.