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. 2019 Dec 2;9:18118. doi: 10.1038/s41598-019-54741-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AGS increases neurotrophins expression levels in vivo. Mice were injected subcutaneously with AGS-499 in a concentration of 6 mg per kg of body mass. After 12 hr., mice were sacrificed. (a) Expression levels were quantified using RT-PCR and normalized to the untreated control (Control) and compared to vehicle treated mice. The results are Mean ± SEM, n = 7 mice per group), ANOVA test **p < 0.01, ***p < 0.001. (b)Immunofluorescence analysis of perfusion fixed frozen hippocampal sections was performed using anti BDNF antibody (red) DAPI staining for nucleus (blue).G-granule layer, H-hilus. Scale bare 200 μm. (c) Relative NGF gene expression in-vivo, in hippocampi (Mean ± SEM, n = 7 mice per group), ANOVA test ***p < 0.001, ****p < 0.0001.