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MEK inhibition promotes PpIX accumulation and 5-ALA-PDT efficacy in a concentration-dependent manner. Moderately sensitive DLD-1 cells were treated with (a) 5-ALA only, (b) U0126 only or (c and d) U0126 followed by 5-ALA. Mean ± SD of cellular fluorescence (left panels) and % cell viability relative to untreated cells (right panels) from three independent experiments are shown. *p < 0.01 by one-way ANOVA with Turkey’s post hoc test
